Sodium, Valporate With Valporic acid


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Sodium valproate and valproic acid are similar medications that are used for the treatment of epilepsy, bipolar disorder, and migraines. These medications are classified as anticonvulsants and work by increasing the levels of gamma-aminobutyric acid (GABA), a neurotransmitter that helps to decrease the activity in the brain and prevent seizures and migraines. Both sodium valproate and valproic acid have similar mechanisms of action 1, pharmacological properties, and side effects. However, there are some differences in the way they are metabolized by the body and their potency. Sodium valproate is usually considered to be more potent than valproic acid and is preferred for the treatment of epilepsy.

Sodium valproate – It is the sodium salt form of valproic acid and is often used interchangeably with valproic acid. It is available in various forms, including tablets, capsules, and syrups, and is administered orally. Sodium valproate is a prodrug, which means that it is converted to valproic acid in the body and exerts its therapeutic effect.

Valproic acid – It is an organic compound that is structurally related to natural fatty acids and is available in tablet, syrup, and injection forms. It has a broad spectrum of anticonvulsant activity and is also used for the treatment of bipolar disorder and migraines. Valproic acid is administered orally, intravenously, or intramuscularly, depending on the route of administration.

How to use Sodium valproate with valproic acid 

Sodium valproate and valproic acid are often used interchangeably The choice of medication and dosage amount depends on the individual patient’s needs and the prescribing doctor’s advice.

Both medications are available in various forms, including tablets, capsules, and syrups, and are administered orally. The dosage amount and frequency of administration may vary depending on the condition being treated, the patient’s age, weight, overall health, and other factors.

Benefits of Sodium valproate with valproic acid

Sodium valproate and valproic acid offer several benefits compared to immediate-release formulations. Here are some potential advantages:

Sustained therapeutic effect: Controlled-release tablets gradually release the medication into the body over an extended period, maintaining a consistent blood concentration of the active ingredients. 

Improved patient compliance: With controlled-release tablets, patients usually need to take less medicine throughout the day compared to immediate-release tablets. This simplifies the dosing regimen and may enhance patient adherence to the prescribed treatment plan. 

Smoother side effect profile: The controlled release of sodium valproate and valproic acid can potentially result in a smoother and more predictable plasma concentration profile. 

Reduced peak and trough variability: Controlled-release tablets provide a more consistent drug release, reducing these fluctuating drug levels and achieving a more stable therapeutic range.

Enhanced convenience: The prolonged duration of action offered by controlled-release tablets means that patients do not have to take medication as frequently throughout the day. 

Potential for improved efficacy: By maintaining a steady concentration of the active ingredients in the bloodstream, controlled-release tablets may optimize the effectiveness of sodium valproate and valproic acid therapy. 

Side Effects of Sodium valproate with valproic acid

Here are the side effects of controlled-release tablets of Sodium Valproate and Valproic Acid (300 mg):

  • Gastrointestinal issues (nausea, vomiting, abdominal pain, diarrhea, constipation)
  • Weight gain
  • Drowsiness and dizziness
  • Hair loss (rare)
  • Liver function changes
  • Pancreatitis (rare)
  • Mood changes (depression, irritability)
  • Blood disorders (rare)


Precautions of  Sodium Vaporate with Valproic Acid 

Precautions for controlled-release tablets of Sodium Valproate and Valproic Acid (300 mg):

  • Take the medicine as your doctor tells you.
  • Tell your doctor about any health problems or drugs you are taking.
  • Pregnancy and breastfeeding: Discuss risks and benefits with your doctor.
  • Be cautious while driving or operating machinery due to potential drowsiness and dizziness.
  • Limit alcohol consumption.
  • Consider alternative or additional contraceptives, as these medications may affect hormonal birth control methods.
  • Carry a medical alert card or inform others about the medication you are taking in case of emergencies.

Additional information

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