Pregabalin IP 75 mg +Nortriptyline HCL 10 mg


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Pregabalin and Nortriptyline Hydrochloride (HCL) Tablets are medications used to treat various conditions, including nerve pain, depression, and anxiety disorders.

Pregabalin is an anticonvulsant drug that primarily works by reducing the release of certain neurotransmitters in the brain, such as glutamate, norepinephrine, and substance P. It is approved for the treatment of neuropathic pain caused by conditions like diabetic neuropathy, postherpetic neuralgia (nerve pain following shingles), fibromyalgia, and spinal cord injury.

Nortriptyline HCL is a tricyclic antidepressant that affects the balance of certain chemicals in the brain, including serotonin and norepinephrine. By restoring the balance of these neurotransmitters, it can help alleviate symptoms of depression and also has analgesic properties, which means it can be used to manage certain types of chronic pain, including neuropathic pain.

In some cases, pregabalin and nortriptyline may be prescribed together, especially when there is comorbid depression and neuropathic pain. The combination of these medications can provide synergistic effects, meaning they work better together than individually, to effectively manage both pain and depressive symptoms.

How To Use 

  • Listen and do what your doctor tells you to do.
  • Take one pill every day, at the same time, whether you eat or not.
  • Take the tablet with water without breaking or chewing it.
  • If you have any problems or worries about side effects, talk to your doctor right away.
  • These tablets might make you feel sleepy or dizzy, so don’t drive or use big machines until you know how the medicine affects you.


Pregabalin and Nortriptyline Hydrochloride (HCL) tablets are commonly used in the treatment of neuropathic pain. Here are some potential benefits associated with these tablets:

Relief from Neuropathic Pain: Pregabalin is an alpha-2 delta ligand that modulates calcium channel activity in nerve cells, helping to decrease pain signals. Nortriptyline, on the other hand, is a tricyclic antidepressant that can help alleviate neuropathic pain. Together, these medications work synergistically to provide relief from the discomfort associated with neuropathic pain conditions.

Improved Quality of Life: Neuropathic pain can significantly impact a person’s quality of life, often leading to reduced physical and psychological well-being. By effectively managing neuropathic pain symptoms, Pregabalin and Nortriptyline Hydrochloride tablets can help individuals regain their functionality, sleep better, and experience an overall improvement in their quality of life.

Enhanced Treatment Options: Combination therapies, such as the use of Pregabalin and Nortriptyline Hydrochloride tablets, offer an alternative for individuals who may not have achieved adequate pain relief or optimal response from a single medication. This combination provides the benefits of both medications, potentially leading to more effective pain management.

Tolerance Prevention: Both Pregabalin and Nortriptyline work through different mechanisms of action to target neuropathic pain. Using a combination therapy can help prevent the development of tolerance to a single drug over time, allowing for continued pain relief without the need for significant dosage adjustments.

Side Effects 

Pregabalin and Nortriptyline Hydrochloride (HCL) tablets may cause side effects. Some common side effects that may occur include:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Weight gain
  • Blurred vision
  • Constipation
  • Nausea
  • Headache

In rare cases, these tablets may cause more serious side effects such as:

  • Suicidal thoughts or behavior
  • Seizures
  • Chest pain
  • Irregular heartbeat
  • Difficulty urinating


Important things to remember while consuming these tablets are:

  • Don’t drink alcohol when you are using these tablets.
  • These pills might make you feel sleepy or dizzy. Be careful when driving or using big machines.
  • These tablets might make you think about hurting yourself or doing things that could harm you. Tell your doctor if you notice any changes in how you feel or act.
  • These tablets can make it harder for you to have a bowel movement. To avoid constipation, make sure to drink lots of liquids and eat foods that are rich in fiber.

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